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Clinical data
Trade namesEffexor, others [1]
License dataUS  DailyMed:  b23637e5-d37f-41b5-ba76-fc053e903bc2
Pregnancy categoryAU: B2 US: C (Risk not ruled out)
Routes of administrationBy mouth
ATC codeN06AX16 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability42±15% [2]
Protein binding27±2% (parent compound), 30±12% (active metabolite, desvenlafaxine) [3]
MetabolismLiver (~50% of the parent compound is metabolised on first pass through the liver) [2] [3]
Elimination half-life5±2 h (parent compound for immediate release preparations), 15±6 h (parent compound for extended release preparations), 11±2 h (active metabolite) [2] [3]
ExcretionKidney (87%; 5% as unchanged drug; 29% as desvenlafaxine and 53% as other metabolites) [2] [3]

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Memory loss is not as severe.Ann Intern Med. 66-167. PubMed Citation Full Text 12.

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It is generally recommended that individuals taking antidepressant medications also find a qualified therapist to speak with.Serotonin-norepinephrine reuptake inhibitors SNRIs may cause symptoms of sexual dysfunction see section 4.

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Continuous dopaminergic stimulation reduces risk of motor complications in parkinsonian primates.Cardio is key to the whole thing, and it sound like you know that. Not to mention the major supplemental depression fighting benefit of regular cardio.

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I finally got home hours and hours later and went straight to bed.I now feel I can do more in my life. I am also less moody.

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The VA/DoD guidelines specifically do not recommend benzodiazepines, tiagabine, guanfacine, valproate, or topiramate. None of these drugs has demonstrated evidence of benefit.For Depression: It changed my life.

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