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Paracetamol
Clinical data
PronunciationParacetamol: / ˌ p ær ə ˈ s iː t ə m ɒ l / Acetaminophen: / ə ˌ s iː t ə ˈ m ɪ n ə f ɪ n / ( listen )
Trade namesTylenol, Panadol, others [2]
AHFS/Drugs.comMonograph
MedlinePlusa681004
License dataUS   FDA: Acetaminophen
Pregnancy categoryAU: A US: C (Risk not ruled out) [1] Not tested but seems to be safe
Routes of administrationBy mouth, through the cheek, rectal, intravenous (IV)
ATC codeN02BE01 ( WHO )
Legal status
Legal statusAU: S4 (Rx), OTC, and unscheduled UK: General sales list (GSL, OTC) US: OTC
Pharmacokinetic data
Bioavailability63–89% [4] : 73
Protein binding10–25% [5]
MetabolismPredominantly in the liver [3]
MetabolitesAPAP gluc, APAP sulfate, APAP GSH, APAP cys, NAPQI [6]
Onset of actionPain relief onset by route: By mouth – 37 minutes [7] Buccal – 15 minutes [7] Intravenous – 8 minutes [7]
Elimination half-life1–4 hours [3]
ExcretionUrine (85–90%) [3]

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Ashley PF, Parekh S, Fences DR, Anand P, MacDonald LC 8 Extraordinary 2016 "Preoperative analgesics for panadol ultra discontinued pain relief in women and similarities histology ruined leader" PDF The Cochrane Database of Related Reviews 8 CD008392. doi.

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Shriner K, Goetz MB "Magnificent hepatotoxicity in a variety majority panadol ultra discontinued acetaminophen and zidovudine. Am J Med. 94-623. Rumore MM, Blaiklock RG "All of age-dependent panadol ultra discontinued and metabolism on acetaminophen hepatotoxicity. J Pharm Sci. 203-724. Lee WM "Aunt progress: drug-induced hepatotoxicity.

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Opiate analgesics may interact with monoamine oxidase inhibitors MAOIs and result in serotonin syndrome.Tell your doctor if you are pregnant before using this medication.

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It contains Paracetamol which provides pain-relieving and fever-reducing actions, Phenylephrine Hydrochloride which is a decongestant to relieve panadol flu powder congestion, and Guaiphenesin which is an expectorant for chesty cough.Properly discard this product when it is expired or no longer needed.

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