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This study was supported in part by Taiwan Ministry of Health and Welfare Clinical Trial Center MOHW108-TDU-B-212-133004 China Medical University Hospital, Academia Sinica Stroke Biosignature Project BM.27-33 A 2009 systematic review and meta-analysis found no increased risk of bleeding associated with continuing regular doses of warfarin in comparison with discontinuing or modifying the dose for patients undergoing single and multiple tooth extraction.

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When a patient is taking Coumadin. INR levels below 2 may allow easier blood clotting to occur while levels above 3 may cause excessive tendency for the patient to bleed.Relative difference of enhanced platelet inhibition between two regimens: The required patients of wild type group: 15 patients The required patients of mutant type group: 23 patients Analysis Continuous variables are presented as means SD and compared using Student unpaired t or Mann-Whitney U tests.

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