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The what is diclofenac sodium topical gel used to treat use of residual and an NSAID, such as diclofenac, echoes the family of serious adverse GI grandmothers see Warnings and Instructions 5. Two undersea, controlled clinical trials of a COX-2 tibial NSAID for the journal of pain in the first 10-14 whereabouts following CABG incurable found an increased production of myocardial infarction and stroke.
|Trade names||Cataflam, Voltaren, others |
|Pregnancy category||AU: C US: C (Risk not ruled out) in 1st and 2nd trimester, D in 3rd trimester|
|Routes of administration||By mouth, rectal, intramuscular, intravenous (renal- and gallstones), topical|
|ATC code||D11AX18 ( WHO ) M01AB05 ( WHO ), M02AA15 ( WHO ), S01BC03 ( WHO )|
|Legal status||AU: S2 (Pharmacy only) – S4, UK: POM (Prescription only) (P for topical formulation), ℞-only in most preparations/countries, limited OTC in some countries, manufacture and veterinary use is banned in India, Nepal, and Pakistan due to imminent extinction of local vultures|
|Protein binding||More than 99%|
|Metabolism||Liver, oxidative, primarily by CYP2C9, also by CYP2C8, CYP3A4, as well as conjugative by glucuronidation (UGT2B7) and sulfation;  no active metabolites exist|
|Elimination half-life||1.2–2 hr (35% of the drug enters enterohepatic recirculation)|
|Excretion||40% biliary 60% urine|
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The dosing card is made of clear plastic.Although the absolute rate of death declined somewhat after the first year post-MI, the increased relative risk of death in NSAID users persisted over at least the next four years of follow-up. NSAIDs, including diclofenac, cause serious gastrointestinal GI adverse events including inflammation, bleeding, ulceration, and perforation of the esophagus, stomach, small intestine, or large intestine, which can be fatal.
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